MOOC Structural Biochemistry（结构生物化学）(南京大学)1465366161 最新慕课完整章节测试答案
Chapter 1 Structure and Function of Proteins
Quiz 1
1、单选题：
The proteinogenic amino acid is
选项：
A: Gamma-GABA
B: Citriline
C: Hydroxyproline
D: Pyrrolysine
E: Cystine
答案: 【 Pyrrolysine】
2、单选题：
The amino acid without optical activity is
选项：
A: Cysteine
B: Lysine
C: Glysine
D: Alanine
E: Leucine
答案: 【 Glysine】
3、单选题：
The amino acid which can be phosphorylated is
选项：
A: Alanine
B: Serine
C: Leucine
D: Proline
E: Asparagine
答案: 【 Serine】
4、单选题：
The amino acid with three pKa is
选项：
A: Alanine
B: Asparagine
C: Cysteine
D: Glutamine
E: Proline
答案: 【 Cysteine】
5、单选题：
If the pKa's of amino, thiol and carboxyl groups of cysteine are 11, 8 and 2 respectively, then its pI will be
选项：
A: 9.5
B: 5
C: 6.5
D: 7
答案: 【 5】
6、单选题：
The amino acid which exists in the trans-membrance alpha-helix most possibly is
选项：
A: Leucine
B: Arginine
C: Aspartic acid
D: Proline
E: Threnine
答案: 【 Leucine】
7、单选题：
The amino acid which cannot react with nitrite is
选项：
A: Glysine
B: Proline
C: Lysine
D: Leucine
E: Valine
答案: 【 Proline】
8、单选题：
The chemical bond stabilizing the secondary structure of proteins is primarily
选项：
A: peptide bond
B: hydrogen bond
C: hydrophobic interaction
D: Van der Waals forces
E: Ionic bond
答案: 【 hydrogen bond】
9、单选题：
The major force driving the folding of proteins is
选项：
A: Hydrogen bond
B: Hydrophobic interaction
C: Disulfide bond
D: Ionic bond
E: Van der Waals forces
答案: 【 Hydrophobic interaction】
10、单选题：
The method that can be used to sequence the proteins is
选项：
A: MS
B: X-ray cystallography
C: NMR
D: Cyro-EM
答案: 【 MS】
11、单选题：
Polylysine at pH 2 can form
选项：
A: alpha-helix
B: beta-sheet
C: beta-turn
D: beta-bulge
E: random coil
答案: 【 random coil】
12、单选题：
Intracellular proteins usually lack
选项：
A: hydrophobic interaction
B: ionic bond
C: disulfide bond
D: van de walls foreces
E: hydrogen bond
答案: 【 disulfide bond】
13、单选题：
Assume the peptide whose sequence is ACDEFGHILMN folds into a stable alpha-helx, the residue that forms a hydrogen bond with amino N of F in this helix is
选项：
A: A
B: C
C: I
D: L
E: E
答案: 【 A】
14、单选题：
Collagens don't form beta-sheet just because they are rich in
选项：
A: Glysine
B: Proline
C: Lysine
D: Alanine
答案: 【 Proline】
15、单选题：
One molecule of Hb can bind at most
选项：
A: one molecule of oxygen
B: two molecule of oxygen
C: three molecule of oxygen
D: four molecule of oxygen
答案: 【 four molecule of oxygen】
16、单选题：
The protein having the quaternary structure is
选项：
A: insulin
B: immunoglobulin
C: myoglobin
D: lactate dehydrogenase
E: ribonuclease A
答案: 【 lactate dehydrogenase】
17、单选题：
If you go from low altitude to high altitude, the 2,3-BPG level will
选项：
A: increase
B: decrease
C: not change
D: be unpredicted
答案: 【 increase】
18、单选题：
The binding of HbA with 2,3-BPG mainly depends on
选项：
A: hydrophobic interaction
B: ionic bond
C: hydrogen bond
D: van der walls forces
答案: 【 ionic bond】
19、单选题：
The 2,3-BPG binding site of HbA are rich in
选项：
A: acidic residues
B: basic residues
C: hydrophobic residues
D: aromatic residues
E: neutral residues
答案: 【 basic residues】
20、单选题：
The condition of increasing the affinity of Hb with O2 is
选项：
A: a increase in CO2
B: a increase in 2,3-BPG
C: a increase in pH
D: a increase in temperature
答案: 【 a increase in pH】
21、单选题：
Amino acid that can form ionic bond with its side chain group and lysine side chain group is
选项：
A: His
B: Arg
C: Asp
D: Leu
E: Gln
答案: 【 Asp】
22、单选题：
Which mutation is most likely to cause the protein to lose its biological activity?
选项：
A: S➝T
B: N➝Q
C: R➝K
D: H➝V
E: L➝V
答案: 【 H➝V】
23、单选题：
The function of the EF-hand is to bind
选项：
A: Calcium ion
B: Magnesium ion
C: Sodium ion
D: Potassium ion
答案: 【 Calcium ion】
24、多选题：
The amino acids that can serve as neurotransmitters include
选项：
A: Asp
B: Asn
C: Glu
D: Gly
E: Gln
答案: 【 Asp;
Glu;
Gly】
25、多选题：
Amino acids having three pKa's include
选项：
A: C
B: K
C: Q
D: Y
E: H
答案: 【 C;
K;
Y;
H】
26、多选题：
The essential amino acids include
选项：
A: K
B: I
C: F
D: Y
E: M
答案: 【 K;
I;
F;
M】
27、多选题：
The hydrophobic amino acids include
选项：
A: A
B: L
C: R
D: Y
E: V
答案: 【 A;
L;
V】
28、多选题：
Residues which tend to be located on the surface of the proteins include
选项：
A: Ser
B: Cys
C: Lys
D: Val
E: Asp
答案: 【 Ser;
Cys;
Lys;
Asp】
29、多选题：
The chemical bonds stabilizing the 3-D structure of hemoglobin include
选项：
A: hydrogen bond
B: hydrophobic interaction
C: ionic bond
D: van der Walls foreces
E: disulfide bond
答案: 【 hydrogen bond;
hydrophobic interaction;
ionic bond;
van der Walls foreces】
30、多选题：
The chaperones involved in protein folding include
选项：
A: HSP60
B: HSP10
C: HSP70
D: PDI
E: PPI
答案: 【 HSP60;
HSP10;
HSP70】
31、多选题：
The amino acid residues which can be recongnized and combined by HSP70 include
选项：
A: K
B: I
C: L
D: D
E: V
答案: 【 I;
L;
V】
32、多选题：
Proline hydroxylation in collagen requires
选项：
A: vitamine C
B: O2
C: hydroxylase
D: alpha-ketoglutarate
E: ferric ion
答案: 【 vitamine C;
O2;
hydroxylase;
alpha-ketoglutarate】
33、多选题：
The ligands whic can bind to HbA include
选项：
A: O2
B: CO2
C: CO
D: 2,3-BPG
E: NO
答案: 【 O2;
CO2;
CO;
2,3-BPG;
NO】
34、多选题：
The methods that can be used to determine the 3-D structure of proteins include
选项：
A: X-ray diffraction
B: NMR
C: MS
D: Cyo-EM
E: Edman degradation
答案: 【 X-ray diffraction;
NMR;
Cyo-EM】
35、判断题：
All peptide bonds directly introduced into the proteins during translation exist in trans.
选项：
A: 正确
B: 错误
答案: 【 正确】
36、判断题：
Proline cannot react with DNFB.
选项：
A: 正确
B: 错误
答案: 【 错误】
37、判断题：
D-Ala and L-Ala have the same molecular weight, same melting point and same water-solubility.
选项：
A: 正确
B: 错误
答案: 【 正确】
38、判断题：
Our human bodies contain 22 proteinogenic amino acids including pyrrolysine.
选项：
A: 正确
B: 错误
答案: 【 错误】
39、判断题：
The peptide bond in the middle of the Pro-X (X represents other amino acids) sequence can be cis.
选项：
A: 正确
B: 错误
答案: 【 错误】
40、判断题：
All proteins have the primary structure, secondary structure and tertiary structure.
选项：
A: 正确
B: 错误
答案: 【 错误】
41、判断题：
The ninhydrin reaction is unique to amino acids, by which we can distinguish amino acids from peptides.
选项：
A: 正确
B: 错误
答案: 【 错误】
42、判断题：
All peptides are synthesized on the ribosomes
选项：
A: 正确
B: 错误
答案: 【 错误】
43、判断题：
Hydrophobic amino acids are water-insoluble.
选项：
A: 正确
B: 错误
答案: 【 错误】
44、判断题：
Alpha-keratin, insulin and immunoglobulin all contain disulfide bonds.
选项：
A: 正确
B: 错误
答案: 【 正确】
45、判断题：
The direction of optical rotation of L-amino acid must be left-handed.
选项：
A: 正确
B: 错误
答案: 【 错误】
46、判断题：
The alpha-helix composed of D-amino acids is usually left-handed
选项：
A: 正确
B: 错误
答案: 【 正确】
47、判断题：
The sequence AGPP in the polypetide can form a beta-turn.
选项：
A: 正确
B: 错误
答案: 【 错误】
48、判断题：
Proline is never found to exist in the alpha-helix.
选项：
A: 正确
B: 错误
答案: 【 错误】
49、判断题：
A lof of energies are released during the protein folding.
选项：
A: 正确
B: 错误
答案: 【 错误】
50、判断题：
Protein folding is an energetically favorable process.
选项：
A: 正确
B: 错误
答案: 【 正确】